|
KMID : 0978920090100040364
|
|
Korean Journal of Clinical Geriatrics
2009 Volume.10 No. 4 p.364 ~ p.373
|
|
|
Augmentation Index and Framingham Risk Score in Asymptomatic Individuals
|
|
Lee Myoung-Jin
Lee Sang-Wha
Lee Hong-Soo
Shim Kyung-Won
Kim Soo-A
Oh Young-A
Woo Eui-Jeong
|
|
|
Abstract
|
|
|
Background: Increased arterial stiffness has been shown to be an independent predictor of early vascular damage and related adverse cardiovascular outcome. The aortic augmentation index (AIx) is a parameter measured noninvasively by using applanation tonometry of radial artery with a validated transfer function to generate the corresponding ascending aortic pressure waveform and is used as a surrogate measure of arterial stiffness and wave reflection. The aim of this study was to assess the relationship between augmentation index and Framingham risk score in asymptomatic individuals.
Methods: We performed a cross-sectional study on 103 Korean men aged 24 to 74 years, who were free from clinical cardiovascular disease. Noninvasive measures of large artery stiffness and wave reflection were aortic augmentation index (AIx), aortic augmentation index adjusted for heart rate (AIx@75) and reflection time (Tr). The Framingham risk score (FRS) was obtained.
Results: In simple linear regression analysis, all indices (AIx, AIx@75 and Tr) were significantly correlated to the FRS (P＜0.001). AIxs differed significantly according to the risk categories (＜10%, 10∼20%,＞20%) by the FRS. The receiver operating characteristic curve demonstrated that an AIx of 12.5%is useful for risk stratification.
Conslusion: Our findings suggest that AIx may be a useful marker of cardiovascular risk in asymptomatic individuals.
|
|
|
KEYWORD
|
|
|
Arterial stiffness, Augmentation index, Cardiovascular risk factors, Framingham risk score
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|